Centers for Disease Control and Prevention: Has the new crown virus appeared in the United States in mid-December last year?

On November 30, local time, Moderna announced that its mRNA technology-based new crown vaccine candidate mRNA-1273 has completed the analysis of the main efficacy data in the phase 3 clinical trial. At the same time, Moderna announced plans to apply to the US FDA for emergency use authorization (EUA) and the European Medicines Agency (EMA) for conditional approval.

Source: Moderna

A total of 30,000 subjects were recruited for this trial. The main efficacy analysis of 196 symptomatic COVID-19 cases showed that the vaccine's effective rate of protecting symptomatic COVID-19 was 94.1%. All 30 severe COVID-19 cases appeared in the control group, which means that this vaccine is 100% effective in preventing severe COVID-19 cases.

In terms of age, race and ethnicity, and gender demographics, the effects are consistent. The 196 COVID-19 cases included 33 elderly (65 years and older) and 42 participants from different ethnic groups (including 29 Hispanic or Latino, 6 Black or African American, and 4 Asian American And 3 multi-ethnic participants).

The safety of the phase 3 study of mRNA-1273 is under continuous review, and no new serious safety issues have been found. According to previous analysis, the most common adverse reactions include pain at the injection site, fatigue, myalgia, arthralgia, headache, and erythema/redness at the injection site. After the second administration, the frequency and severity of spontaneous adverse reactions in the mRNA-1273 group increased. (Source: Moderna)

US Centers for Disease Control: The new crown virus may have appeared in the US in mid-December last year

On November 30, in the Clinical Infectious Diseases e-newsletter, the CDC staff stated that “the new coronavirus infection cases in the United States may have appeared in December 2019, earlier than the previous discovery.”

Source: Clinical Infectious Diseases

The American Red Cross collected 7389 routine blood donations archived samples collected from December 13 to January 2019 in 9 states (California, Connecticut, Iowa, Massachusetts, Michigan, Oregon) , Rhode Island, Washington and Wisconsin) residents were tested for anti-CDS-CoV-2 antibodies. It was found that 106 blood samples contained antibodies to the new coronavirus.

These findings indicate that SARS-CoV-2 may have been introduced into the United States before January 19, 2020, earlier than the first reported case.

The author said that as the world continues to fight the new crown, this study will help expand health officials' understanding of the epidemic.